미래를 창조하는 포스텍 화학공학과
Functional hydrogel micropatterns for biomedical application
This seminar deals with fabricating multiscale hydogel-based biopatterns and its biomedical application such as tissue engineering and biosensing
First, fabrication of hydrogel-incorporating nanofiber will be described. Micropatterned scaffolds were prepared by fabricating poly(ethylene glycol) (PEG) hydrogel microstructures on electrospun nanofiber matrix, and produced as free-standing and bidirectionally-porous sheets. Tissue engineering application using resultant scaffold such as regeneration of damaged salivary glands will be introduced.
Second, we developed a novel silver-based metal-enhanced fluorescence (MEF) biosensing platform that consisted of poly(ethylene glycol)(PEG) hydrogel microstructures entrapping silica-coated AgNPs (Ag@SiO2). AgNPs were coated with different thickness of silica to optimize the MEF effects.
The final application is the use of bioresponsive hydrogel for biosensing. we monitored the volume changes of bioresponsive hydrogels using the concept of moiré patterns. To generate a moiré pattern, a hydrogel grating with microgroove patterns was fabricated via replica molding, which was then overlaid with a reference grating with a different pitch size. Although the change in the pitch size of the hydrogel grating via external stimuli was small, a much greater signal could be obtained when moiré signals were used.