미래를 창조하는 포스텍 화학공학과
제목: Multilayered Nano-Coatings for Medical Engineering
내용: Recent developments in biomedical engineering, novel cell culture techniques, and newly discovered chemicals as a replacement of the growth factors have opened new area toward the engineered technique of biomedical applications, for use in both research and clinical applications. Ideal bio-platform must be biocompatible that is to say, they should show both proper surface stability for the promotion of cell attachment and functions with drug delivery. However, plenty of challenges are still in progress, as the reason for the high compatibility of polymer film in cell culture environment and precisely controlled functional release of their drugs..
Layer-by-layer (LbL) self-assembly technic has been developed and used to prepared biocompatible multilayer films and polyelectrolyte capsules for drug delivery. Certain drug molecules, such as active proteins, cytokine, growth factors, enzymes, nucleic acids, and DNA, have been immobilized into nano-sized multilayer films. The advantages of LbL multilayer films as drug delivery systems include the sustained drug release through controlling the film physical & chemical properties, in addition multilayer films have the potential to protect drug molecules from losing their biological functions, and the film preparation process is simple and can be automated.
In this presentation, we prepared the cell friendly platform by take full advantages of LbL assembly with evenly distributed drug loading by nano-sized layer assembly. The nano-films are prepared by various materials including not only synthetic-, natural-polymers but also functional materials such as growth factors, cytokines which are resulting different film degradation profiles. These results lay a cornerstone for future studies to achieve the multi-functional nanofilms including programmed loading/release of drugs for therapeutic purposes.
Zoom 회의 참가
회의 ID: 382 631 3167