제목: Computational Protein Design in Modern Medicine

내용: Protein drug designed by utilizing the tools of de novo protein design rationally and computationally has bee used to study the mechanisms by which chemical or mechanical signals sensed by cells and alter cell function. De novo designed proteins can deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer functional tissues outside of the body for organ replacement. In the talk, we mainly discuss computational protein design approach with controlled folding of structure and dynamic functionality to integrate with biological complexity and perform tailored, high-level functions in the body. As the first subject, this talk will describe a target barrier penetrable peptide platform technology and development of brain specific target protein drugs. We also discuss new computational design of proteins that bind highly functionalized small molecules and successfully engineer a series of binding modes of hybrid structures. This novel design approach for construction of specific receptor binding in target barrier and small molecule binding hybrid proteins, as well as the unique structural motifs for this purpose that we identified, suggest a promising role for biomedical applications such as sensor, imaging and therapeutic drug in modern medicine.