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Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate

Title of paper
Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate
Author
[차형준교수 연구실] 순차적 약물 방출을 통한 무봉합 피부 이식용 의료접착제 개발
Publication in journal
Chemical Engineering Journal, Vol. 446, p137272, 202210
Publication date
20221015

 

[Abstract]

Conventional skin grafting procedures such as suturing and stapling are accompanied by pathologic scarring with functional and psychological sequelae; severe scars need a prolonged recovery period, increasing the chance of wound infections or graft contraction. The present study develops a novel bioadhesive delivering dual drugs to minimize scar formation and accelerate wound healing during full-thickness skin grafting. The bioadhesive is prepared via coacervation of a mussel protein and shows high adhesive strength in both porcine skin and in vivo rodent models; furthermore, it sustainably releases dual drugs (allantoin and epithelial growth factor) to enhance re-epithelialization and collagen deposition while simultaneously reducing scar formation. The proposed dual-drug-in-bioadhesive coacervate may ideally meet the requirements of the wound healing process and is a promising candidate for sutureless full-thickness skin grafting.

 

DOI: 10.1016/j.cej.2022.137272

Link: Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate - ScienceDirect