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Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification

Title of paper
Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification
Author
[차형준교수 연구실] 해양바이오미네랄화 기반의 뼈대체제 개발
Publication in journal
ACS Applied Bio Materials 4(8), p6046–6055 (2021)
Publication date
20210816


[Abstract]

Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophore-derived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.

 

DOI: 10.1021/acsabm.1c00346

LINK: https://pubs.acs.org/doi/10.1021/acsabm.1c00346