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정기세미나

미래를 창조하는 포스텍 화학공학과

Targeted Drug Delivery Inspired by Real-Time Molecular Imaging

일자
2021.12.6(월)
시간
17:00 ~ 18:15
연사
권익찬 박사
장소
온라인 ZOOM
소속
한국과학기술연구원

제목:  Targeted Drug Delivery Inspired by Real-Time Molecular Imaging

 

내용: For decades, molecular imaging, capable of monitoring intercellular/intracellular molecular processes in organisms, has provided valuable information for a variety of research fields. Biomarkers such as enzymes, receptors, and proteins can provide information for early diagnosis of diseases and monitoring of therapeutic effects, and thus can be used as targets for molecular imaging. Among them, molecular imaging technology based on receptor-ligand interaction is emerging as a promising strategy for monitoring intractable diseases such as cancer. However, the basic requirement for this kind of imaging probe is to provide disease-specific information along with high imaging sensitivity. Here, we developed a self-quenching imaging probe capable of emitting fluorescence (activation) via a de-quenching reaction after internalization via receptor-ligand binding. Demonstrations of EGFR or CD47 target specific fluorescence signals will be presented in this lecture.

 

1. Y.J. Ko, et al, J. Controlled Release, 323, 376-386 (2020)
2. H.Y. Kim, et al, J. Controlled Release, 328, 222-236 (2020)
3. Y.J. Ko, et al, J. Controlled Release, 305, 1-17 (2019)

 

참여주소: ID: 344 455 5324 / PW: POSTECH

https://us02web.zoom.us/j/3444555324?pwd=eGx2Ukx3SUFmUkllRi9PcjRRVTNaZz09