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미래를 창조하는 포스텍 화학공학과

Stem cell-loaded adhesive immiscible liquid for regeneration of myocar…

Year of publication
Title of paper
Stem cell-loaded adhesive immiscible liquid for regeneration of myocardial infarction
Author
[차형준 교수 연구실]
Publication in journal
Journal of Controlled Release 32(10), pp602-615, 2020
Publication date
20200510

 

Abstract: Myocardial infarction (MI) causes serious loss of cardiac muscle and dysfunction. To restore MI, exogenous stem cells should be efficiently delivered. However, due to severe physical and physiological cardiac environment, recent strategies have faced challenges, including low cell persistence, low integration, and delayed therapeutic effects. Herein, we proposed mesenchymal stem cell (MSC) therapeutic platform using adhesive protein-based immiscible condensed liquid system (APICLS) derived from bioengineered mussel adhesive protein (MAP). With high encapsulation efficiency and survival rate of encapsulated MSCs, APICLS was successfully grafted by intramyocardial injection and distributed throughout the scarred myocardium. Its underwater adhesiveness and biocompatibility fostered integration with damaged tissue, resulting in high cell persistence and maximized paracrine effects. Bioactive molecules released from APICLS with MSCs induced angiogenesis and cardioprotection, delayed cardiac remodeling, reduced fibrosis, and recovered contractive force. Thus, our proposed strategy represents an innovative approach for recovering infarcted cardiac tissues with damaged structural and contractive function.

 

DOI: 10.1016/j.jconrel.2020.02.047

 

LINK: https://linkinghub.elsevier.com/retrieve/pii/S0168365920301371