닫기

연구

Research Outcome

미래를 창조하는 포스텍 화학공학과

Polysaccharide–Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanc…

Year of publication
Title of paper
Polysaccharide–Hydrophobic Nanoparticle Hybrid Nanoclusters for Enhanced Performance in Magnetic Resonance/Photoacoustic Imaging
Author
[차형준교수 연구실]
Publication in journal
Biomacromolecules 20(11), p4150-4157, 2019
Publication date
20191111

 

[Abstract]

Polysaccharide–nanoparticle (NP) hybrid nanoclusters have great potential to revitalize diverse bioapplications; however, fabricating polysaccharide-based hybrid nanoclusters composed of high-quality NPs generated in the organic phase remains a challenge. Here, using calcium alginate as a polysaccharide/tetramethylammonium hydroxide (TMAOH) combination, we report a novel approach to the design of alginate–hydrophobic magnetic–plasmonic core–shell (MPCS) NP hybrid nanoclusters (A-MPCS HNCs). Furthermore, we observe the dependence of the formation of A-MPCS HNCs on the TMAOH concentration. The enhanced performance in both magnetic resonance r2 relaxivity and photoacoustic (PA) signals and the biocompatibility/bioactivity as well as the in vivo performance of A-MPCS HNCs shows them to be a promising magnetic resonance/photoacoustic dual-mode imaging agent. Our strategy could open doors to the use of other precious high-quality nanomaterials created in the organic phase via well-established synthetic chemistry in the design of alginate–hydrophobic nanomaterial hybrid nanoclusters, giving rise to novel and multifarious bioapplications.
 

DOI: 10.1021/acs.biomac.9b01008

LINK: https://pubs.acs.org/doi/10.1021/acs.biomac.9b01008