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Novel In Silico Analyses of Repetitive Spider Silk Sequences to Unders…

Year of publication
Title of paper
Novel In Silico Analyses of Repetitive Spider Silk Sequences to Understand the Evolution and Mechanical Properties of Fibrous Protein Materials
Author
[차형준교수 연구실]
Publication in journal
Biotechnology Journal 14(10), p1900138, 2019
Publication date
20191004

 

[Abstract]

The mechanical properties of spider silks have diverged as spiders have diversely speciated. Because the main components of silks are proteins, it is valuable to investigate their sequences. However, silk sequences have been regarded as difficult information to analyze due to their imbalance and imperfect tandem repeats (ITR). Here, an in silico approach is applied to systemically analyze a group of silk sequences. It is found that every time new spider groups emerge, unique trimer motifs appear. These trimer motifs are used to find additional clues of evolution and to determine relationships with mechanical properties. For the first time, crucial evidence is provided that shows silk sequences coevolved with spider species and the mechanical properties of their fibers to adapt to new living environments. This novel approach can be used as a platform for analyzing other groups of ITR‐harboring proteins and to obtain information for the design of tailor‐made fibrous protein materials.

 

Doi: https://doi.org/10.1002/biot.201900138

LINK: https://onlinelibrary.wiley.com/doi/full/10.1002/biot.201900138