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미래를 창조하는 포스텍 화학공학과

Mussel-inspired enzyme immobilization and dual real-time compensation …

Year of publication
Title of paper
Mussel-inspired enzyme immobilization and dual real-time compensation algorithms for durable and accurate continuous glucose monitoring
Author
[차형준교수 연구실]
Publication in journal
Biosensors and Bioelectronics 143 (2019), 111622
Publication date
20191015


[Abstract]

Blood glucose sensing is very important for diabetic management. It is shifting towards a continuous glucose monitoring because such a system can alleviate patient suffering and provide a large number of glucose measurements. Here, we proposed a novel approach for the development of durable and accurate enzymatic continuous glucose monitoring system (CGMS). For the long-term durable and selective immobilization of glucose oxidase on a microneedle electrode, a biocompatible engineered mussel adhesive protein was employed through efficient electrochemical oxidation strategy. For the accurate performance in in vivo environments, we also suggested dual real-time compensated algorithms to cover both temperature and time-lag differences. After pre-clinical and pilot-clinical evaluations, we confirmed that our proposed CGMS has an outstanding performance compared with various commercially available continuous systems and achieves comparable performance to disposable glucose sensors.

 

DOI: 10.1016/j.bios.2019.111622

LINK: https://www.sciencedirect.com/science/article/pii/S0956566319307018