미래를 창조하는 포스텍 화학공학과
Single-molecule Dynamics of DNA Repair
- 2017.04.24(월) 17:00
- 이종봉 교수
- POSTECH 물리학과
Although the temporal and mechanistic order of molecular events is essential for life, the downstream signaling mechanism in various biological processes has been poorly understood. However, since real-time observation of individual biomolecules and their complex going through biochemical reactions enables us to observe transient intermediate states, multiple pathways, rare molecular events, and mechanical and thermodynamic information, this real-time single-molecule imaging is capable of elucidating the salient features of a variety of biological processes. We have developed a variety of single-molecule techniques to explore the mechanics of DNA mismatch repair. I will introduce how we solved the mechanism that has been controversial for decades using real-time single-molecule imaging.